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In iOS development, can you explain the concept of threading? Additionally, identify the different thread types available within iOS, and explain the circumstances in which each type is most applicable.

Can you outline the design for an efficient file handling app for the iOS ecosystem?

Provide an in-depth overview of the different methodologies for executing asynchronous method calls in iOS. Explore the role and purpose of completion handlers, dissect the intricacies of async/await, and touch upon other valuable techniques leveraged to proficiently handle asynchronous tasks.

Outline your strategy for creating a photo upload and sharing application similar to Instagram, highlighting the crucial features and their implementation.